1

Better AI For Understanding Life on Earth: Predict First, Design Later

Generative AI is generating much enthusiasm on potentially advancing biological design in computational biology. In this paper we take a somewhat contrarian view, arguing that a broader and deeper understanding of existing biological sequences is …

Session Introduction: Biological molecular function: methods and benchmarks for finding function in biological dark matter

The accurate determination of biological molecular function remains one of the most significant challenges in computational biology, with vast areas of biological “dark matter” persisting in microbiomes, viruses, and unexplored sequence space. To …

Session Introduction: Precision Medicine: Multi-modal and multi-scale methods to promote mechanistic understanding of disease

Precision medicine focuses on developing treatments and preventative strategies tailored to an individual’s genomic profile, lifestyle, and environmental context. The Precision Medicine sessions at the Pacific Symposium on Biocomputing (PSB) have …

Session Introduction: Precision Medicine: Innovative methods for advanced understanding of molecular underpinnings of disease

Precision medicine, also often referred to as personalized medicine, targets the development of treatments and preventative measures specific to the individual’s genomic signatures, lifestyle, and environmental conditions. The series of Precision …

The Universal Language of Life--Leveraging Deep Transfer Learning to Model the Biogeosphere

(Protein) Networking and Dating

COMPUTATIONAL APPROACHES TO UNDERSTANDING THE EVOLUTION OF MOLECULAR FUNCTION

The following sections are included:IntroductionOverview of ContributionsReferences.