Identifying Crohn's disease signal from variome analysis

Abstract

After years of concentrated research efforts, the exact cause of Crohn’s disease (CD) remains unknown. Its accurate diagnosis, however, helps in management and preventing the onset of disease. Genome-wide association studies have identified 241 CD loci, but these carry small log odds ratios and are thus diagnostically uninformative.

Publication
Genome Medicine
Yanran Wang
Yanran Wang
PhD Candidate

Machine learning and sequencing data.

Maximilian Miller
Maximilian Miller
PostDoctoral Associate

improving variant effect predictions, deciphering metagenomes and creating an efficient service infrastructure

Yana Bromberg
Yana Bromberg
Principal Investigator - Associate Professor of Bioinformatics

My research focuses on deciphering the DNA blueprints of life’s molecular machinery

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